FIG 1.

Viral shedding in rhesus macaques following live vaccine EGD administration. The GI of rhesus macaques was administered 10⁶ TCID₅₀ SARS-CoV-2 via EGD. (A) Log₁₀ gRNA copies/g stool (limit of 200 copies/mL) or (C) Log₁₀ sgRNA copies/g stool were assessed in stools in sham controls and in vaccinated animals following challenge. (B) Log₁₀ gRNA copies/swab or (D) Log₁₀ sgRNA copies/swab (limit of 50 copies/swab) were assessed in rectal swabs (RS) in sham controls and in vaccinated animals following challenge. Red lines reflect median values. (E) Peak viral loads in stool on day 1 following vaccination. Red lines reflect median viral loads. P values indicate two-sided Mann-Whitney tests.