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. 2022 Jan 26;96(2):e01689-21. doi: 10.1128/JVI.01689-21

FIG 3.

FIG 3

(A and B) Monomeric MAb-mediated internalization of virions is similar with and without complement on monocytes (A) and on neutrophils (B). Each data point represents the median fold change of the internalization score for the seven antibodies (Abs) that capture HIV-1iGFP/JRFL (2G12, VRC01, 3BNC117, NIH46 G54W, HIVIG, 10E8, and 4E10) as well as for the immune complexes formed by cross-linking NIH45-46 G54W with a goat anti-human antibody (data points with the highest values; Fig. 1). When expressed as the median fold change (combining median values with and without complement), antibody-mediated internalization by monocytes is similar to internalization by neutrophils for the seven monomeric Abs, though there may be slightly better internalization of the anti-human antibody-cross-linked immune complex on neutrophils (C). Mann-Whitney tests were used to calculate the P values.

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