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T1L/T3DM2 is more virulent than T1L in neonatal mice. (A) Neonatal C57BL/6 mice were inoculated orally with 104 PFU of T1L or T1L/T3DM2 viruses. Mice were monitored for 25 days. (B) Neonatal C57BL/6 mice were inoculated intracranially with 100 PFU of T1L or T1L/T3DM2 viruses. Mice were monitored for 20 days. ****, P < 0.0001 (determined by the log-rank test, in comparison to T1L).
