Table 3.
Demographics and clinical characteristics of patients with multisystem inflammatory syndrome in children
| Variables | AKI, n=26 | Non-AKI, N=31 | P Value |
| Age, yr | |||
| Median (range) | 10 (2–20) | 4 (0–17) | <0.001 |
| Sex | |||
| Boys | 14/26=54% | 14/31=45% | 0.60 |
| Girls | 12/26=46% | 17/31=55% | |
| Hispanic ethnicity | 8/26=31% | 9/31=29% | >0.99 |
| BMI≥85th percentile | N=26; 15/26=58% | N=30; 13/30=43% | 0.42 |
| LV systolic dysfunction | N=26; 15/26=58% | N=28; 2/28=7% | <0.001 |
| Lymphopenia | 24/26=92% | 18/31=26% | 0.006 |
| Defined as <1500/mm3 | |||
| IL-6, pg/ml | N=20 | N=15 | 0.02 |
| Median (range) | 274.5 (32.0–315.0) | 46.7 (3.0–315.0) | |
| Peak ferritin, ng/ml | N=26 | N=29 | <0.001 |
| Median (range) | 670.5 (284–100,000) | 233.1 (19.9–2769) | |
| Peak fibrinogen, mg/dl | N=26 | N=24 | 0.10 |
| Median (range) | 624 (166–875) | 501.5 (273–838) | |
| Peak d-dimer, μg/ml FEU | N=26 | N=28 | 0.35 |
| Median (range) | 3.9 (0.5–426) | 2.9 (0.3–20.0) | |
| Peak LDH, U/L | N=25 | N=27 | 0.81 |
| Median (range) | 339 (207–4087) | 356 (178–1295) | |
| Peak CRP, mg/L | N=26 | N=30 | 0.01 |
| Median (range) | 211 (29.4–300) | 135.1 (0.21–300.0) | |
| Peak ESR, mm/h | N=20 | N=23 | 0.97 |
| Median (range) | 56.5 (23–130) | 59.0 (0–130) | |
| Peak procalcitonin, ng/ml | N=23 | N=24 | 0.02 |
| Median (range) | 3.6 (0.2–126.9) | 1.6 (0.1–42.1) | |
| Significant proteinuria | N=25 | N=29 | 0.58 |
| Defined as ≥2+ on dipstick | 11/25=44% | 10/29=34% |
Patients for whom certain data were unavailable or missing were excluded from analysis regarding that factor. Lymphopenia is defined as having an absolute lymphocyte count <1500/mm3 (or <2000/mm3 in children younger than 6 years of age). BMI, body mass index; LV, left ventricular; LDH, lactate dehydrogenase; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate.