Table 2.

The association of clinical characteristics with total glomerular number per kidney and single-nephron parameters

Clinical Variables	Non-globally Sclerotic Glomeruli (Number Per Kidney)		Globally Sclerotic Glomeruli (Number Per Kidney)		Total Glomeruli (Number Per Kidney)		Mean Glomerular Volume (×106 μm3)		Single-nephron GFR (nl/min)		Single-nephron Urinary Protein Excretion (μg/d)
	Estimate	P value	Estimate	P value	Estimate	P value	Estimate	P value	Estimate	P value	Estimate	P value
Univariable
CKD categorya	−196,284	<0.001	50,918	<0.001	−145,366	<0.001	0.327	<0.001	2.136	0.21	1.406	<0.001
Hypertension	−154,544	0.02	−5651	0.88	−160,195	0.02	0.403	0.06	10.507	0.047	1.432	<0.001
UPE ≥1 g/d	−190,543	<0.001	56,199	0.053	−134,345	0.02	0.337	0.048	−2.034	0.63	2.949	<0.001
Multivariable b
CKD categorya	−172,720	<0.001	49,712	<0.001	−123,007	<0.001	0.311	<0.001	2.290	0.29	1.225	<0.001
Hypertension	−93,575	0.08	−35,891	0.33	−129,466	0.046	0.186	0.36	11.420	0.04	0.600	0.15
UPE ≥1 g/d	20,944	0.66	−12,605	0.70	8338	0.88	−0.265	0.14	−9.301	0.06	1.940	<0.001

BSA, body surface area; CKD, chronic kidney disease; GFR, glomerular filtration rate; UPE, urinary protein excretion.

^aFive categories of CKD stage were defined: eGFR levels ≥90, 60–89, 45–59, 30–44 and<30 ml/min per 1.73 m², respectively.

^bAdjusted for age, sex, and BSA in addition to CKD stage, hypertension, and UPE.