Selected reports of exogenous terpenoid toxicity to E. coli under typical production conditionsa.
| Terpenoids and derivatives | Minimum concentration that causes growth reduction but not complete inhibition (g L−1) | MIC (>indicates that total inhibition was not reached at that concentration) (g L−1) | T (°C) | Scale (mL) | Reference |
|---|---|---|---|---|---|
| Hemiterpenoids | |||||
| Isoprenol | 1.5 | 2.4 | 37 | ∼1? | 274 |
| Monoterpenoids | |||||
| α−Pinene | 4.29 | >42.9 | 37 | 0.8 | 275 |
| α−Pinene | 0.429 | 1.28 | 37 | 5 | 281 |
| 1,8-Cineole | 37 | 0.1 | 321 | ||
| Geraniol | 1.78 | 8.89 | 30 | 5 | 273 |
| Geraniol | 0.222 | 0.444 | 37 | 0.8 | 275 |
| Geraniol | 0.075 | 0.300 | 37 | 1 | 163 |
| -Geranyl acetate | 4.58 | >45.8 | 37 | 0.8 | 275 |
| -Geranyl acetate | 0.5 | 37 | 1 | 163 | |
| Myrcene | >7.94 | >7.94 | 30 | 5 | 273 |
| Sabinene | 1 | >5 | 31 | 50 | 161 |
| Linalool | 1 | 37 | 0.2 | 159 | |
| Limonene | 1.05 | 42.05 | 30 | 0.1? | 264 |
| Limonene | >25.23 | >25.23 | 30 | 0.15 | 263 |
| Limonene | 3.36 | 8.41 | 37 | 5 | 281 |
| Limonene | 0.05 | 0.21 | 37 | 0.8 | 275 |
| -Perillyl alcohol | 4.79 | 30 | 0.15 | 263 | |
| Sesquiterpenoids | |||||
| α−Bisabolene | >180 | >180 | 37 | 1 | 322 |
| Bisabolol | >27.6 | >27.6 | 30 | 0.15 | 263 |
| (−)-α−Bisabolol | 5 | >5 | 309 | ||
| γ-Bisabolene | >27 | >27 | 30 | 0.15 | 263 |
| Farnesol | >26.61 | >26.61 | 30 | 0.15 | 263 |
| α−Farnesene | >24.39 | >24.39 | 30 | 0.15 | 263 |
| Diterpenoids | |||||
| Cis-Abienol | >2 | >2 | 37 | 10 | 183 |
| Cembratriene-ol | >2 | >2 | 37 | 2 | 45 |
| Sclareol | >2 | >2 | 37 | 10 | 185 |
Where concentrations were expressed as “%”, “% v/v” was assumed for liquid terpenoids and g L−1 were calculated using density.