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. 2022 Jan 13;6(2):368–372. doi: 10.1182/bloodadvances.2020003876

Figure 1.

Figure 1.

Mutation profile of the MRD cohort. (A) Recurrently mutated genes and functionally important hits. Patients are depicted as columns; genes are depicted as rows. Previously identified MM associated genes (supplemental Table 3) are highlighted in red rectangles; star symbols indicate potentially actionable targets. Total number of single nucleotide variants (SNVs) in particular patients is given on the top. Driver frequencies from other studies were obtained from 5 papers.3–7 (B-C) Kaplan-Meier curves showing association of PFS with RAS-related pathways. Pathways KRAS.600_UP.V1_UP included synthetic lethal partners of oncogenic KRAS. Ras protein signal transduction pathway is a series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state. List of genes included in respective pathways is provided below each graph. FDR, false discovery rate; mut, mutated; wt, wild type.