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. 2022 Jan 5;11:e72357. doi: 10.7554/eLife.72357

Table 1. Risk factors in relation to body mass index: differences in mean, variability and skewness estimated by GAMLSS (n = 6007).

Risk factor % NO distribution BCCG distribution
Mean SD Median CoV Skewness*
Female (ref) 52.4% 28.1 6.1 26.9 0.22 1.10
Male 47.6% 28.7 4.6 28.2 0.16 0.75
 Unadjusted difference, % (SE) 1.9 (0.5) –27.6 (1.8) 4.1 (0.4) –23 (1.8) 0.48 (0.11)
 Adjusted difference, % (SE) 2.2 (0.5) –27.4 (1.8) 4.4 (0.4) –22.6 (1.8) 0.54 (0.11)
Non-manual (ref) 36.3% 27.7 5.2 27 0.19 1.15
Manual social class 63.7% 28.8 5.5 28 0.19 0.90
 Unadjusted difference, % (SE) 4.0 (0.5) 6.1 (1.9) 4.4 (0.5) 6 (1.9) 0.39 (0.11)
 Adjusted difference, % (SE) 3.8 (0.5) 5.5 (1.9) 4.3 (0.4) 5.6 (1.9) 0.40 (0.12)
Physically active (ref) 73% 28.1 5.2 27.4 0.19 0.97
Inactive 27% 29.1 6.0 28.3 0.21 0.94
 Unadjusted difference, % (SE) 3.3 (0.6) 13.5 (2.1) 2.9 (0.5) 10.4 (2.1) 0.08 (0.12)
 Adjusted difference, % (SE) 3.3 (0.6) 12.1 (2.1) 3.1 (0.5) 9.3 (2.1) 0.12 (0.12)
*

Skewness is estimated as the Box-Cox power (that is, the power required to transform the outcome to a normal distribution); differences are the absolute difference in Box-Cox power in each subgroup estimated by GAMLSS. GAMLSS estimates multiple distribution moments simultaneously; thus, differences may not exactly correspond to descriptive comparisons reported above.

Estimates mutually adjusted for sex, social class and physical inactivity.

NO: normal distribution; BCCG: Box-Cox Cole and Green distribution: SD: standard deviation; CoV: coefficient of variation; GAMLSS: Generalized Additive Models for Location, Scale and Shape; SE, standard error.