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Stability of ester, carbamate, and triazole MCL analogs in blood serum. Percent intact drug for MCL analogs after incubating with PBS, 50% and 100% mouse blood serum. A) MCL-19 (ester), B) MCL-39 (carbamate), and C) MCL-64 (triazole). Data represents mean ± SD (n = 3). **p < 0.01 and ****p < 0.0001 represents significance between 0 and 24 h time points for each incubation condition using two-way ANOVA followed by Sidak’s multiple comparisons.
