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Degradable ester bonds are partially protected from degradation via NP encapsulation. Percent intact drug after incubation in 50% mouse serum. A) MCL-19, B) MCL-39, and C) MCL-64. Data represents mean ± SEM (n = 3–9). *p < 0.05 represents statistical differences between free drug and NP loaded drug at each time point using two-way ANOVA followed by Sidak’s multiple comparisons test. D) Schematic of serum proteins interacting with ester analogs in free and in NP form.
