Table 1.
LC50 of MCL and its analogs against M9-ENL1 and MV411 cells.
| Class | Compound | CLogP1 | LC50 [μM] M9-ENL1 | LC50 [μM]2 MV-411 |
|---|---|---|---|---|
| Parent | MCL | 1.7 | 15.4 ± 1.1 | 5.6 ± 2.8 |
| Esters | MCL-6 | 2.8 | 20 ± 3 | 1.4 ± 0.3** |
| MCL-9 | 2.9 | 4.8 ± 1 | 1.9 ± 0.1** | |
| MCL-13 | 4.0 | 1.8 ± 1 | 1.8 ± 0.7** | |
| MCL-14 | 3.7 | 10 ± 2 | 1.0 ± 0.1** | |
| MCL-16 | 4.5 | 5.2 ± 1 | 1.0 ± 0.4** | |
| MCL-19 | 4.5 | 4.1 ± 1.1 | 1.7 ± 0.9** | |
| Carbamates | MCL-38 | 3.6 | 4.3 ± 1 | 2.9 ± 0.6 |
| MCL-39 | 3.2 | 3.3 ± 1 | 2.9 ± 1.4 | |
| Triazole | MCL-64 | 4.0 | 2.2 ± 0.1 | 1.2 ± 0.5** |
1
CLogP represents an estimation of the logarithm of partition coefficient [n-Octanol/water] as determined by ChemDraw;
2
Half-maximal lethal concentration. Data represents mean ± std (n = 3).
**
p < 0.01 represents significant differences between MCL analogs and MCL using one-way ANOVA and Dunnett’s multiple comparisons test used to compare MCL analogs to MCL.