Skip to main content
. 2022 Jan 26;9(2):e1133. doi: 10.1212/NXI.0000000000001133

Figure 3. PGRN−/− Mice Develop Exacerbated EAU.

Figure 3

WT and PGRN−/− mice of C57BL/6 background were induced for EAU. (A) Quantification of clinical score of the 2 groups from day 7 to day 13. (B) Pathologic scores of the 2 EAU groups on day 13. (C) Detection of intracellular expression of IL-17, IFN-γ, and Foxp3 by CD4+ T cells in spleen by flow cytometry. (D) Quantitative RT-PCR analysis of IFN-γ, IL-17, IL-10, and foxp3 in the splenocytes. Data are shown as mean ± SEM from 2 to 3 independent experiments with a total of 10 mice per group. *p < 0.05, **p < 0.01, and ***p < 0.001. EAU = experimental autoimmune uveitis; IL = interleukin; IFN = interferon; PGRN = progranulin; RT-PCR = real-time PCR; Th = T helper; WT = wild type.