Table 3.

Analysis of circadian gene expression in the gastrocnemius of control and alcohol-treated mice

Muscle	One-Way ANOVA Results				Cosinar Results
	0–24 h		24–48 h		0–24 h	24–48 h
	P Value		P Value		P Value	P Value
Gene	Control	EtOH	Control	EtOH	Con vs. EtOH
Clock	0.12	0.13	0.0004	0.09	0.59	0.05
Bmal1	<0.0001	<0.0001	<0.0001	0.01	<0.0001	0.03
Per1	<0.0001	0.61	<0.0001	0.33	<0.0001	0.40
Per2	<0.0001	<0.0001	<0.0001	0.01	0.02	0.03
Per3	<0.0001	0.0001	0.0002	0.27	0.20	0.03
Cry1	0.0002	0.02	0.02	0.97	<0.0001	0.001
Cry2	0.002	0.14	0.004	0.30	<0.0001	0.01
Reverbα	<0.0001	<0.0001	<0.0001	0.01	0.89	<0.0001
Rorα	0.004	0.61	0.23	0.12	<0.0001	<0.0001
Myod1	<0.0001	0.001	0.01	0.52	<0.0001	0.11
Dbp	<0.0001	<0.0001	<0.0001	0.01	0.0001	0.12
Tef	0.001	0.10	0.03	0.21	<0.0001	0.003
Bhlhe40	0.001	0.06	0.05	0.14	0.001	0.93

Analysis of circadian gene expression in the gastrocnemius of control and alcohol-treated mice. One-way ANOVAs were used to evaluate changes in gene expression overtime representative of circadian rhythmicity. A sum-of-squares F test was used to determine whether a single cosinor model fit both control and EtOH-treated groups to further indicate differences in rhythmicity between the two groups. Values are P values from control and alcohol-treated female mice at the time points indicated, with bold values indicating significance.