Table 2.
Maternal and fetal plasma glucose and lactate values at 135 days and immediately before the first oxytocin infusion (pre), at the end of the first infusion (5 min), and at the end of the 5-min infusions delivered 24, 48, and 72 h
| Maternal |
Fetal |
|||||||
|---|---|---|---|---|---|---|---|---|
| Plasma glucose, mM |
Plasma lactate, mM |
Plasma glucose, mM |
Plasma lactate, mM |
|||||
| Sample time | Control | Cortisol | Control | Cortisol | Control | Cortisol | Control | Cortisol |
| Pre, first oxytocin infusion | 3.7 ± 0.1 (10) |
3.6 ± 0.1 (11) |
0.69 ± 0.06 (11) |
0.81 ± 0.08 (11) |
1.0 ± 0.1 (11) |
1.1 ± 0.1 (11) |
1.68 ± 0.11 (11) |
1.81 ± 0.18 (11) |
| 5 min (after first oxytocin infusion) |
3.9 ± 0.1 (11) |
3.8 ± 0.1 (11) |
0.77 ± 0.06 (10) |
0.87 ± 0.08 (11) |
1.0 ± 0.1 (10) |
1.1 ± 0.1 (10) |
1.82 ± 0.12 (10) |
1.82 ± 0.18 (10) |
| After oxytocin infusion at 24 h | 3.8 ± 0.2 (10) |
3.5 ± 0.2 (11) |
0.69 ± 0.04 (11) |
1.18 ± 0.23 (11) |
1.0 ± 0.1 (11) |
1.1 ± 0.1 (11) |
2.02 ± 0.22 (11) |
2.18 ± 0.12 (11) |
| No DCA | +DCA | No DCA | +DCA | No DCA | +DCA | No DCA | No DCA | +DCA | +DCA | No DCA | +DCA | No DCA | +DCA | No DCA | +DCA | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| After oxytocin infusion at 48 h | 3.9 ± 0.1 (4) |
4.8 ± 0.5 (5) |
4.0 ± 0.1 (4) |
3.6 ± 0.2 (5) |
0.8 ± 0.1 (4) |
0.7 ± 0.2 (5) |
0.8 ± 0.1 (4) |
1.4 ± 0.4 (4) |
1.0 ± 0.1 (5) |
1.2 ± 0.3 (5) |
1.2 ± 0.1 (4) |
1.0 ± 0.1 (5) |
1.8 ± 0.2 (4) |
3.3 ± 0.9 (5) |
2.0 ± 0.2 (4) |
3.0 ± 1.0 (5) |
| After oxytocin infusion at 72 h | 4.3 ± 0.4 (4) |
3.7 ± 0.1 (4) |
3.7 ± 0.22 (4) |
3.8 ± 0.2 (5) |
0.7 ± 0.1 (4) |
0.3 ± 0.0 (4) |
0.6 ± 0.0 (4) |
0.4 ± 0.1 (4) |
1.2 ± 0.1 (4) |
0.7 ± 0.4 (4) |
1.1 ± 0.1 (4) |
1.0 ± 0.1 (4) |
1.9 ± 0.6 (4) |
1.3 ± 0.3 (4) |
2.2 ± 0.2 (4) |
2.0 ± 0.7 (4) |
Dichloroacetate (DCA) was infused into the ewes starting at 48 h and continuing until 72 h or delivery of the fetus. Data are expressed as mean ± SE (n, number of fetuses).