Table 5.
Correlation of metabolite abundance in fetal/newborn hearts to mean arterial pressure (MAP), heart rate (HR), or QRS duration
| Metabolite | r | P Value | Confidence Scorea |
|---|---|---|---|
| Correlation to MAP | |||
| Alanine | 0.79 | 4.06E-04 | 4 |
| Glutamine | 0.64 | 1.01E-02 | 4 |
| Glycerol | 0.76 | 1.05E-03 | 4 |
| Lactate | 0.60 | 1.88E-02 | 4 |
| Isobutyryl-carnitine* | −0.70 | 3.71E-03 | 2 |
| ITP | −0.54 | 3.82E-02 | 3 |
| Pantothenate | 0.79 | 4.54E-04 | 3 |
| UK1* | 0.58 | 2.20E-02 | NA |
| Unsaturated fatty acidsb | 0.59 | 1.96E-02 | NA |
| Correlation to HR | |||
| Lactate | 0.60 | 1.35E-02 | 4 |
| Glycerol | 0.56 | 2.40E-02 | 4 |
| Taurine | −0.58 | 1.95E-02 | 4 |
| Isobutyryl-carnitine | −0.65 | 6.09E-03 | 2 |
| UK1* | 0.54 | 2.98E-02 | NA |
| Correlation to QRS duration | |||
| Glycerophosphocholine | −0.63 | 1.51E-02 | 3 |
| OL8 | 0.61 | 1.97E-02 | NA |
| UK6* | −0.65 | 1.23E-02 | NA |
| Serine | −0.63 | 1.60E-02 | 4 |
*Metabolite peaks from CPMG.
aConfidence scale is defined as follows: 1) putatively characterized compounds or compound classes, 2) 1 D NMR matches to literature and/or database (BMRB and/or HMDB), 3) HSQC matches on COLMARm, 4) HSQC and HSQC-TOCSY match on COLMARm, and 5) verified by spiking.
bPotential assignments of this peak are listed in Supplemental Table S3.
CPMG, Carr–Purcell–Meiboom–Gill; HSQC, heteronuclear single-quantum coherence; OL, overlap, OL8, threonine overlaps with phosphorylcholine; BMRB, Biological Magnetic Resonance Bank; HMDB, Human Metabolome Database; COLMAR, Complex Mixture Analysis by NMR;TOCSY, total correlation spectroscopy; UK, unknown metabolites.