Figure 1.
Heightened cardiometabolic risk in offspring born to metabolically compromised dams. In 12-wk-old chow-fed Wt male (A) and female (B) offspring born to Wt or Hetdb pregnancies (Wt/Wt vs. Wt/Het), whole body fat mass was measured by TD-NMR. Fasting plasma triglyceride levels (C), total cholesterol (D), and nonesterified FFA (E) were evaluated in 6-mo-old female offspring using colorimetric assays. Insulin sensitivity (F) was assessed after a 6-h fast by injecting 0.5 IU/kg insulin (IP) and sampling blood glucose from the tail (n = 6–8).