Table 2.

Correlation of Lp(a) and clinical variables with platelet reactivity

A		Intrinsic platelet reactivity			On-DAPT platelet reactivity
	Stimulating reagent	Arachidonic acid (500 mg/L)	Collagen (2.5 µg/ml)	ADP (5 µM)	Collagen (2.5 µg/ml)	ADP (5 µM)
Lp(a)	Correlation coefficient	0.018	0.000	− 0.024	0.042	0.009
	p value	0.423	0.997	0.291	0.261	0.818
Age	Correlation coefficient	0.020	0.047	0.137	0.087	0.133
	p value	< 0.001	0.041	< 0.001	0.018	< 0.001
Body mass index	Correlation coefficient	0.020	0.031	0.028	0.035	0.091
	p value	0.382	0.179	0.226	0.341	0.014
Diabetes	Correlation coefficient	0.037	0.036	0.025	0.117	0.128
	p value	0.111	0.111	0.279	0.002	0.001
History of smoking	Correlation coefficient	− 0.058	− 0.036	− 0.057	0.061	0.042
	p value	0.011	0.117	0.013	0.099	0.259
Creatinine level	Correlation coefficient	0.016	− 0.079	− 0.041	− 0.011	0.014
	p value	0.483	0.001	0.074	0.765	0.708
Platelet count	Correlation coefficient	− 0.035	− 0.056	− 0.074	− 0.119	− 0.114
	p value	0.129	0.014	0.001	0.001	0.002

B		Intrinsic platelet reactivity			On-DAPT platelet reactivity
		CD41	CD62P	PAC-1	CD41	CD62P	PAC-1
Lp(a)	Correlation coefficient	0.001	0.020	0.005	0.005	− 0.027	− 0.032
	p value	0.957	0.409	0.827	0.903	0.491	0.426
Age	Correlation coefficient	− 0.058	0.062	0.006	− 0.038	− 0.003	0.043
	p value	0.017	0.011	0.808	0.342	0.938	0.274
Body mass index	Correlation coefficient	− 0.029	− 0.035	− 0.054	0.044	0.055	0.082
	p value	0.230	0.156	0.026	0.272	0.164	0.038
Diabetes	Correlation coefficient	− 0.005	0.011	− 0.056	0.013	0.079	0.069
	p value	0.848	0.664	0.022	0.747	0.046	0.080
History of smoking	Correlation coefficient	− 0.016	− 0.030	− 0.021	0.051	0.081	0.077
	p value	0.512	0.224	0.392	0.196	0.040	0.051
Creatinine level	Correlation coefficient	0.065	− 0.026	− 0.063	0.019	− 0.001	− 0.036
	p value	0.008	0.284	0.009	0.627	0.978	0.368
Platelet count	Correlation coefficient	− 0.135	− 0.031	− 0.110	− 0.152	− 0.035	− 0.127
	p value	< 0.001	0.211	< 0.001	< 0.001	0.380	0.001

Correlation of Lp(a) and clinical variables with platelet reactivity measured by light transmission aggregometry (A) and with surface protein expression following stimulation with ADP (B). Correlation coefficient and p value by Spearman correlation. Surface protein expression was measured under stimulation by ADP. DAPT dual antiplatelet therapy