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. 2021 Apr 29;43(2):260–272. doi: 10.1038/s41401-021-00661-0

Fig. 2. Sustained imbalance of redox homeostasis in the BLA of extinction-deficit rats.

Fig. 2

a Experimental protocols of the cue-induced fear conditioning paradigm. b The percentage of freezing during 4 CS-alone trials. The rats that showed a high freezing rate (≥50%) were defined as Ext Deficit. c, d GSH and GSSG contents in rat BLA tissues after fear conditioning were detected (n = 10). e, f GSH and GSSG contents were assayed in the hippocampus or mPFC of rats after fear conditioning (n = 8). g–k Oxidative biomarkers, including GPx, MDA, SOD, CAT and total thiol, were measured in rat BLA tissues after fear conditioning (n = 8–10). All data are expressed as the mean ± SEM. *P < 0.05, **P < 0.01 vs. the naïve group; #P < 0.05, ##P < 0.01 vs. the Cond group; $P < 0.05, $$P < 0.01 vs. the Ext group. Data were analyzed by one-way ANOVA with a post hoc LSD test.