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. 2022 Jan 26;12:1408. doi: 10.1038/s41598-022-05468-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Regression performance of an attention-guided multi-plane ResNet-50 model. Model performance of the highest-scoring architecture visualized above. (a) Correlation between predicted brain age and ground truth (R² = 0.945) is represented by the line of best fit (blue). The dashed line is the ideal regression, where prediction equals true age. (b) Differences between predictions and ground truth are shown on the modified Bland–Altman plot. Corresponding 5%, 10th, 25th, 50th, 75th, 90th, and 95th quantile curves based on local piecewise regression analysis are drawn.