Table 1.
Biological characteristics of T acute lymphoblastic leukemia according to fusion transcripts status.
| RT-MLPA | Positive | Negative | All | ||||
|---|---|---|---|---|---|---|---|
| 104 | 418 | 522 | |||||
| Fusion groups | MLLT10 n = 37 (7%) | KMT2A/SET n = 34 (7%) | ABL1 n = 22 (4%) | ETS n = 6 (1%) | Other n = 5 (1%) | 80% | |
| Transcripts |
PICALM-MLLT10 (23) DDX3X-MLLT10 (8) NAP1L1-MLLT10 (4) XPO1-MLLT10 (2) |
SET-NUP214 (18) KMT2A-AFDN (10) KMT2A-MLLT1 (4) KMT2A-ELL (1) KMT2A-? (1) |
NUP214-ABL1 (19) BCR-ABL1 (2) ETV6-ABL1 (1) |
ETV6-NCOA2 (3) STMN1-SPI1 (2) TCF7-SPI1 (1) |
NUP98-RAP1GDS1 (3) PCM1-FLT3 (1) P2RY8-CRLF2 (1) |
||
| Population | |||||||
| Age mean (range) | 23.4 (3–44) | 27.9 (8–63) | 23.1 (4–61) | 4.5 (1–8) | 18.8 (8–34) | 25.9 (1–78) | 25.4 (1–78) |
| Pediatric cases | 41% (n = 15) | 24% (n = 8) | 55% (n = 12) | 100 % (n = 6) | 60% (n = 3) | 39% (n = 162) | 39% (n = 206) |
| Phenotype | |||||||
| Immature | 3% (n = 1) | 4% (n = 1) | 7% (n = 1) | 33% (n = 1) | 33% (n = 1) | 10% (n = 34) | 9% (n = 39) |
| γδ-lineage | 84% (n = 27) | 81% (n = 22) | 27% (n = 4) | 0 | 33% (n = 1) | 26% (n = 85) | 34% (n = 139) |
| αβ-lineage | 12% (n = 4) | 15% (n = 4) | 67% (n = 10) | 67 % (n = 2) | 33% (n = 1) | 64% (n = 214) | 57% (n = 235) |
| Not available | 14% (n = 5) | 21% (n = 7) | 32% (n = 7) | 50% (n = 3) | 40% (n = 2) | 20% (n = 85) | 21% (n = 109) |
| Homeobox Genes Deregulation | |||||||
| HOXA9 | 95% (n = 35) | 100% (n = 34) | 5% (n = 1) | 0 | 60% (n = 3) | 20% (n = 82) | 30% (n = 155) |
| TLX1 | 0 | 0 | 14% (n = 3) | 0 | 0 | 14% (n = 60) | 12% (n = 63) |
| TLX3 | 0 | 0 | 73% (n = 16) | 0 | 0 | 14% (n = 57) | 14% (n = 73) |
| Negative | 5% (n = 2) | 0 | 14% (n = 3) | 100% (n = 6) | 40% (n = 2) | 55% (n = 231) | 47% (n = 244) |
All means are compared against the Negative group with Wilcoxon test or Student test depending on the Shapiro test result. All proportions are compared against the Negative group with Pearson’s χ2 test or for small values with the Fisher exact test. Results with p ≤ 0.05 are displayed in bold. Immature T-ALL are TCR- and cTCRβ-. αβ-lineage T-ALL are TCRαβ or preαβ (TCR-) but with cTCRβ+ . γδ-lineage T-ALL are TCRγδ.