Table 2.

Polygenic risk scores.

Polygenic risk scoresa, mean (SD)	SCZ	BD	HC	P valueb	SMD vs HC
Autoimmune diseases and CRP
CD	0.04 (1.0)	0.03 (0.9)	−0.07 (1.0)	0.18	n/a
IBD	0.01 (1.0)	−0.04 (1.0)	0.05 (1.0)	0.13	n/a
PSOR	−0.03 (0.9)	−0.04 (0.9)	0.08 (0.9)	0.06	HC > SMD
RA	−0.002 (1.0)	−0.04 (1.0)	−0.02 (1.0)	1.0	n/a
SLE	−0.03 (0.8)	−0.05 (0.7)	−0.12 (0.7)	0.74	n/a
T1D	0.05 (0.8)	0.10 (0.8)	0.06 (0.8)	0.12	n/a
CRP	−0.02 (0.9)	0.00 (0.9)	−0.04 (0.9)	0.84	n/a
Mental disorders
ADHD	0.05 (1.0)	0.11 (1.0)	−0.09 (0.9)	<0.001	SMD > HC
ANX	0.17 (1.0)	0.12 (0.9)	−0.09 (1.0)	<0.001	SMD > HC
ASD	0.03 (1.1)	0.08 (1.1)	−0.01 (1.0)	0.15	n/a
MDD	0.06 (1.0)	0.01 (1.0)	−0.08 (1.0)	0.04	SMD > HC
PTSD	0.05 (1.0)	−0.02 (0.9)	−0.11 (0.9)	0.002	SMD > HC
Cognitive traits
COG	−0.08 (1.0)	0.02 (1.0)	0.07 (1.0)	0.02	HC > SMD
EA	0.11 (1.0)	0.08 (1.0)	0.17 (1.0)	0.10	HC > SMD
Personality traits
EXTRA	0.04 (1.0)	0.05 (1.0)	−0.02 (1.0)	0.16	n/a
NEURO	0.01 (1.0)	−0.04 (1.0)	−0.08 (1.0)	0.16	n/a
OPEN	0.10 (1.0)	0.03 (1.0)	−0.01 (1.0)	0.10	SMD > HC

ADHD attention-deficit hyperactivity disorder, ANX anxiety, ASD autism spectrum disorder, BD bipolar spectrum disorders, CD Crohn’s disease, COG cognition, CRP C-reactive protein, EA educational attainment, EXTRA extraversion, HC healthy controls, IBD inflammatory bowel disease, MDD major depressive disorder, n/a not applicable, NEURO neuroticism, OPEN openness, PC principal component, PSOR psoriasis, PTSD post-traumatic stress disorder, RA rheumatoid arthritis, SCZ schizophrenia spectrum disorders, SD standard deviation, SMD severe mental disorders (SCZ and BD), SLE systemic lupus erythematosus, T1D type 1 diabetes.

^aStandardized values.

^bP value of SMD vs HC: ANCOVA with adjustments for PC1, PC2, and genetic batch.