Table 3.
Main effects of polygenic risk scores on immune markersa.
| Immune marker | df | F-ratio | P value | ηp2 | PP changec | |
|---|---|---|---|---|---|---|
| Total sample | ||||||
| PRS-PSOR | sgp130 | 1,1118 | 5.86 | 0.02 | 0.005 | −0.2 |
| PRS-ANX | sIL-2R | 1,1050 | 5.19 | 0.02 | 0.005 | 0.6 |
| IL-18 | 1,1520 | 4.77 | 0.03 | 0.003 | −2.0 | |
| PRS-EA | IL-1Ra | 1,1087 | 6.46 | 0.01 | 0.006 | 0.0 |
| sIL-2R | 1,1050 | 4.79 | 0.03 | 0.005 | 0.0 | |
| IL-18 | 1,1520 | 6.93 | 0.01 | 0.005 | −0.7 | |
| Subsample SCZ-HCb | ||||||
| PRS-PSOR | sgp130 | 1,885 | 4.95 | 0.03 | 0.006 | −0.2 |
| PRS-ANX | IL-18 | 1,1196 | 3.92 | 0.05 | 0.003 | −2.1 |
| PRS-EA | IL-1Ra | 1,861 | 4.09 | 0.04 | 0.005 | 0.4 |
| IL-18 | 1,1196 | 5.89 | 0.02 | 0.005 | −0.4 | |
| Subsample BD–HCb | ||||||
| PRS-EA | IL-1Ra | 1,709 | 7.27 | 0.01 | 0.010 | −0.2 |
| IL-18 | 1,1065 | 5.20 | 0.02 | 0.005 | −0.6 | |
ANX anxiety, BD bipolar spectrum disorders, df degrees freedom, EA educational attainment, IL-18 interleukin-18, IL-1Ra interleukin-1 receptor antagonist, ηp2 partial eta squared, PP percentage points, PRS polygenic risk score, PSOR psoriasis, SCZ schizophrenia spectrum disorders, sIL-2R soluble interleukin-2 receptor, sgp130 soluble glycoprotein 130.
aIndependent variables: PRS, age, sex, freezer storage time, patients vs healthy controls, genetic principal components 1 and 2 and genetic batch; dependent variables: immune markers.
bSubsample SCZ-HC: participants with schizophrenia spectrum disorders and healthy controls; subsample BD–HC: participants with bipolar spectrum disorders and healthy controls.
cPercentage points change in immune marker plasma-level difference between diagnostic subgroups and healthy controls by adding PRS to the statistical model.