a, b The mRNA levels of the ECM regulators Mmp-2, Mmp-13, Mmp-14, Timp-1, Timp-2, and Timp-3 in iWAT extracted from 21-week-old male Orm1+/+ and Orm1−/− mice (n = 3 per group). c Western blot analysis of iWAT extracted in a (n = 3 per group). d–i Densitometric quantification of the data in c. *P < 0.05, **P < 0.01, ***P < 0.001 by the Student’s t test.