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. 2021 Apr 19;43(2):367–375. doi: 10.1038/s41401-021-00666-9

Fig. 3. ORM administration ameliorates the abnormal synthesis and degradation of ECM components in the iWAT of HFD mice.

Fig. 3

a The mRNA levels of Col1a1, Col3a1, and Col6a3 in iWAT extracted from C57BL/6J mice fed a chow diet or 60% HFD (12 weeks) and treated with intraperitoneal injection of vehicle or 50 mg/kg ORM for 7 consecutive days (n = 4 per group). b, c The mRNA levels of the ECM regulators Mmp-2, Mmp-13, Mmp-14, Timp-1, Timp-2, and Timp-3 in iWAT extracted from the mice in a (n = 4 per group). d Western blot analysis of iWAT extracted from the mice in a (n = 3 per group). e–m Densitometric quantification of the data in d. *P < 0.05, **P < 0.01, ***P < 0.001 by one-way ANOVA with the Tukey’s test.