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. 2021 Apr 19;43(2):367–375. doi: 10.1038/s41401-021-00666-9

Fig. 5. ORM stimulates AMPK activity and inhibits TGF-β1 signaling in the iWAT of obese mice.

Fig. 5

a Western blot analysis of iWAT extracted from C57BL/6J mice fed a chow diet or 60% HFD (12 weeks) and treated with intraperitoneal injection of vehicle or 50 mg/kg ORM for 7 consecutive days (n = 3). b Densitometric quantification of the data in a. c The mRNA levels of Tgf-β1 of iWAT extracted in a (n = 4). d Western blot analysis of iWAT extracted from C57BL/6J mice and db/db mice treated with intraperitoneal injection of vehicle or 50 mg/kg ORM for 7 consecutive days (n = 3). e Densitometric quantification of the data in d. f The mRNA levels of Tgf-β1 of iWAT extracted in d (n = 4). *P < 0.05, **P < 0.01, ***P < 0.001 by one-way ANOVA with the Tukey’s test.