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. 2021 Apr 19;43(2):367–375. doi: 10.1038/s41401-021-00666-9

Fig. 7. Proposed mechanism by which ORM is involved in adipose tissue fibrosis.

Fig. 7

ORM1-deficient mice showed significant increases in fat mass and excessive collagen deposition. Exogenous administration of ORM activates adipose tissue AMPK, inhibits TGF-β1 levels, and reduces the expression of collagen and ECM mediators, thus alleviating adipose tissue fibrosis.