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. 2021 Sep 30;43(2):285–294. doi: 10.1038/s41401-021-00778-2

Fig. 5. HACE1 knockdown exacerbated behavior impairments in the MPTP-induced mouse model.

Fig. 5

a Experimental procedures of MPTP-induced PD model and lentiviruses’ injection. b Time staying on the rod. c Immunohistochemistry of TH (1: NC, 2: HACE1-shRNA, 3: NC+MPTP, 4: HACE1-shRNA+MPTP). d TH expression in the striatum was assessed by Western blot. e Immunohistochemistry of Iba1 (1: NC, 2: HACE1-shRNA, 3: NC+MPTP, 4: HACE1-shRNA+MPTP). The data were expressed as the mean ± SD (n = 3) or mean ± SEM (n = 15), *P < 0.05, **P < 0.01, ***P < 0.001