Fig. 7. Schematic diagram of HACE1 role in regulating the neuroinflammatory responses of BV2 microglial cells.

HACE1 targets Rac1 for proteasomal degradation, thus regulating neuroinflammation. In the absence of HACE1, the activity of Rac1 significantly increases, leading to a higher level of ROS and the activation of the JAK2-STAT1 signaling pathway.