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. 2021 Apr 6;43(2):446–456. doi: 10.1038/s41401-021-00642-3

Fig. 5. C0818 inhibited the Ras/Raf/MEK/ERK and PI3K/AKT pathways through the degradation of Hsp90 clients in HCC cells.

Fig. 5

a SiRNA reduced the expression level of Hsp90 in HepG2 and Sk-Hep-1 cells. b Hsp90 knockdown reduced the viability of HepG2 and Sk-Hep-1 cells. c The expression levels of Hsp90 clients were measured by Western blotting. d The expression levels of PI3K, AKT, P-AKT, mTOR and P-mTOR were measured by Western blotting. The data are presented as the mean ± SD (n = 3). *P < 0.05 versus the control.