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. 2021 Dec 31;24:385–399. doi: 10.1016/j.omto.2021.12.019

Figure 4.

Figure 4

scRNA-seq analysis of tumor-infiltrating T cells

(A) t-SNE plot of tumor-infiltrating BBζ CAR8 (pink), 28ζ CAR8 (green), and 28BBζ CAR8 (orange) cells and CD8 UNT (black) and CD4/8 UNT (gray) cells. CD4 and CD8 gene distribution is shown in the lower t-SNE plots. (B) CD8 regulatory T cell (Treg cell) subset analysis of the five treatments by determining FOXP3 and IL-2RA (CD25) gene expression. FOXP3−IL-2RA− (gray), FOXP3−IL-2RA+ (brown), FOXP3+IL-2RA− (orange), and FOXP3+IL-2RA+ (yellow) distribution is shown in the t-SNE plot. (C and D) Quantification of the percentage (C) and cell count (D) of each population.