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. 2021 Dec 31;24:385–399. doi: 10.1016/j.omto.2021.12.019

Figure 5.

Figure 5

Transcriptional signatures of tumor-infiltrating BBζ CAR8, 28ζ CAR8, and 28BBζ CAR8 cells

(A) Heatmap of top 20 differential expression genes from each group in the comparison of BBζ (pink), 28ζ (green), and 28BBζ (orange) CAR-T cells. (B) Gene expression of XCL1, XCL2, KLRB1, IL-2RA, CTLA-4, LAG-3, TNFRSF18 (GITR), BATF, and PD-1 in BBζ (pink), 28ζ (green), and 28BBζ (orange) CAR-T cells. (C) HLA class II gene expression in BBζ, 28ζ, and 28BBζ CAR-T cells. CD74, HLA-DRA, HLA-DRB5, HLA-DRB1, HLA-DQA1, HLA-DQB1, HLA-DMA, HLA-DPA1, and HLA-DPB1 are shown in the heatmap after removing seven low-expression genes HLA-DQB1-AS1, HLA-DQA2, HLA-DQB2, HLA-DOB, HLA-DMB, HLA-DOA, and CIITA (Figure S6). (D) Violin plot of mean Z score expression of MHC class II gene expression in BBζ CAR8 (pink), 28ζ CAR8 (green), and 28BB CAR8 (orange). A Kruskal-Wallis rank-sum test was applied.