Table 3.
Characteristics of patients transplanted for AHN due to HDS DILI vs non-HDS DILI.
| HDS DILI (n = 41) | Non-HDS DILI (n = 695) | P | Non-APAP, non-HDS DILI (n = 335) | P | |
|---|---|---|---|---|---|
| Sex: | |||||
| Female | 26 (63.4%) | 502 (72.2%) | 182 (67.7%) | ||
| Male | 15 (36.6%) | 193 (27.8%) | 0.22 | 87 (32.3%) | 0.59 |
| Age (years): | |||||
| Median [IQR] | 36 [24.5–52.5] | 35 [25–47] | 0.65 | 43 [27–54] | 0.18 |
| ≤19 | 3 (7.3%) | 82 (11.8%) | 33 (12.3%) | ||
| 20–29 | 12 (29.3%) | 179 (25.8%) | 44 (16.4%) | ||
| 30–39 | 9 (22.0%) | 152 (21.9%) | 41 (15.2%) | ||
| 40–49 | 6 (14.6%) | 145 (20.9%) | 56 (20.8%) | ||
| 50–59 | 8 (19.5%) | 81 (11.7%) | 55 (20.5%) | ||
| ≥60 | 3 (7.3%) | 56 (8.1%) | 0.64 | 40 (14.9%) | 0.24 |
| Ptrend 0.52 | Ptrend 0.34 | ||||
| Ethnicity: | |||||
| White | 22 (53.7%) | 466 (67.1%) | 140 (52.0%) | ||
| Black | 4 (9.8%) | 119 (17.1%) | 70 (26.0%) | ||
| Hispanic | 6 (14.6%) | 66 (9.5%) | 33 (12.3%) | ||
| Asian | 7 (17.1%) | 21 (3.0%) | 15 (5.6%) | ||
| Other | 2 (4.9%) | 23 (3.3%) | 0.001 | 11 (4.1%) | 0.03 |
| Education beyond high school:1 | |||||
| No | 14 (40.0%) | 269 (54.7%) | 100 (52.9%) | ||
| Yes | 21 (60.0%) | 223 (45.3%) | 0.09 | 89 (47.1%) | 0.16 |
| Year transplanted: | |||||
| 1994–1999 | 6 (15.4%) | 125 (18.6%) | 71 (27.0%) | ||
| 2000–2004 | 1 (2.6%) | 131 (19.4%) | 53 (20.2%) | ||
| 2005–2009 | 4 (10.3%) | 178 (26.4%) | 56 (21.3%) | ||
| 2010–2014 | 15 (38.5%) | 139 (20.6%) | 46 (17.5%) | ||
| 2015–2020 | 15 (36.6%) | 122 (17.6%) | <0.001 | 43 (16.0%) | <0.001 |
| Ptrend 0.001 | Ptrend <0.001 | ||||
| MELD score at listing2, median [IQR] | 31.5 [28–37] | 37 [30–42] | 0.02 | 33 [29–40] | 0.37 |
| MELD score at transplant3, median [IQR] | 35 [30–42.25] | 36 [29–41] | 0.70 | 34 [29–41] | 0.38 |
Tests for significance with chi-squared tests or Fisher exact tests for categorical variables, Kruskal-Wallis rank tests for continuous variables, and univariate logistic regression for trends.
Missing for n = 209 patients (6 with HDS DILI and 203 with non-HDS DILI including 80 with non-APAP/non-HDS DILI).
Available for patients waitlisted in 2002 onward only and additionally missing for n = 4 patients with non-HDS DILI due to APAP from those years.
Available for patients waitlisted in 2002 onward only and additionally missing for n = 4 patients with non-HDS DILI due to APAP from those years.
AHN: acute hepatic necrosis, APAP: acetaminophen, DILI: drug-induced liver injury, HDS: herbal and dietary supplements, IQR: interquartile range, MELD = Model for End-stage Liver Disease