Table 1.
Demographic, clinical, imaging, and personality descriptive statistics of BLSA study participants.
| Amyloid | Tau | |||
|---|---|---|---|---|
|
| ||||
| CN (N=196) | Full (N=216) | CN (N=95) | Full (N=103) | |
| Age, years | 77.74 (8.56) | 78.55 (8.72) | 76.04 (8.59) | 76.85 (8.89) |
| Female | 101 (51.5%) | 107 (49.5%) | 55 (57.9%) | 58 (56.3%) |
| Black | 35 (17.9%) | 38 (17.6%) | 17 (17.9%) | 19 (18.4%) |
| Other | 10 (5.1%) | 10 (4.6%) | 6 (6.3%) | 6 (5.9%) |
| White | 151 (77.0%) | 168 (77.8%) | 72 (75.8%) | 78 (75.7%) |
| Education, years | 17.18 (2.39) | 17.24 (2.43) | 17.66 (2.43) | 17.60 (2.51) |
| Diagnosis: MCI^ | 0 (0%) | 13 (6%) | 0 (0%) | 6 (5.8%) |
| Diagnosis: Dementia^ | 0 (0%) | 5 (2.3%) | 0 (0%) | 0 (0%) |
| APOE e4 carrier | 56 (28.9%) | 63 (29.6%) | 26 (28.0%) | 29 (29.0%) |
| Hippocampus (cm3) | 7.29 (0.76) | 7.25 (0.80) | 7.34 (0.76) | 7.29 (0.77) |
| CESD ≥ 16 | 12 (6.1%) | 16 (7.4%) | 5 (5.3%) | 6 (5.8%) |
| Amyloid PiB+ | 57 (29.1%) | 72 (33.3%) | 21 (22.1%) | 26 (25.2%) |
| Amyloid mean cortical | 1.09 (0.18) | 1.11 (0.18) | 1.07 (0.15) | 1.11 (0.18) |
| Amyloid Precuneus | 1.17 (0.23) | 1.19 (0.24) | 1.15 (0.19) | 1.19 (0.24) |
| Tau Entorhinal | 1.03 (0.17) | 1.04 (0.18) | 1.03 (0.17) | 1.04 (0.18) |
| Tau Fusiform | 1.16 (0.22) | 1.16 (0.21) | 1.16 (0.22) | 1.16 (0.21) |
| Tau Inferior temporal gyrus | 1.30 (0.21) | 1.31 (0.20) | 1.30 (0.21) | 1.31 (0.20) |
| Tau Hippocampus | 1.31 (0.27) | 1.32 (0.29) | 1.31 (0.27) | 1.32 (0.29) |
| Neuroticism | 44.37 (8.65) | 44.74 (8.76) | 43.44 (9.19) | 43.76 (9.27) |
| Extraversion | 49.59 (10.12) | 49.63 (10.14) | 49.46 (11.79) | 49.43 (11.65) |
| Openness | 51.63 (9.93) | 51.07 (9.89) | 52.10 (10.03) | 51.33 (10.16) |
| Agreeableness | 54.46 (9.29) | 54.30 (9.18) | 55.19 (10.05) | 55.09 (10.07) |
| Conscientiousness | 52.33 (9.87) | 51.87 (10.08) | 54.12 (10.47) | 53.99 (10.49) |
Notes. CN = Cognitively normal. CESD = Center for Epidemiological Studies-Depression. MCI = Mild Cognitive Impairment. PiB = 11C-Pittsburgh compound B. In parenthesis are SD or percentages. Age at the time of personality assessment. APOE data was missing for 3 individuals. PiB statistics are distribution volume ratio (DVR) and tau are standardized uptake value ratio (SUVR).
^
The difference between CN and Full sample includes impaired participants, of whom two had impairment other than MCI or dementia.