Table 2.

Associations between personality traits and amyloid and tau in BLSA study participants.

	PiB mean cortical			PiB+			Entorhinal Tau
	M1	M2	M3	M1	M2	M3	M1	M2	M3
Cognitively	r	r	r	OR (95% CI)	OR (95% CI)	OR (95% CI)	r	r	r
Normal (CN)
Neuroticism	.24**	.26**	.24**	1.68 (1.20–2.34)**	1.69 (1.20–2.38)**	1.72 (1.18–2.49)**	.18	.18	.24*
Extraversion	−.08	−.04	−.01	.80 (.58–1.09)	.84 (.60–1.18)	.89 (.63–1.25)	−.20	−.20	−.24*
Openness	−.12	−.13	−.09	.71 (.52–.98)*	.71 (.51–.99)*	.76 (.54–.1.07)	−.20*	−.21*	−.22*
Agreeableness	−.14*	−.14	−.14	.81 (.59–1.10)	.80 (.57–1.11)	.78 (.56–1.10)	−.12	−.11	−.15
Conscientiousness	−.23**	−.20**	−.18*	.61 (.44–.86)**	.64 (.45–.91)*	.64 (.44–.93)*	−.28**	−.30**	−.42**
Full sample
Neuroticism	.21**	.20**	.20**	1.64 (1.21–2.22)**	1.64 (1.19–2.25)**	1.65 (1.16–2.35)**	.19	.18	.23*
Extraversion	−.07	−.01	.01	.80 (.60–1.06)	.89 (.66–1.21)	.95 (.69–1.30)	−.20*	−.17	−.20
Openness	−.16*	−.14	−.12	.63 (.47–.85)**	.66 (.48–.91)*	.70 (.50–.97)*	−.23*	−.22*	−.23*
Agreeableness	−.12	−.10	−.11	.80 (.60–1.07)	.81 (.59–1.11)	.81 (.59–1.12)	−.09	−.08	−.09
Conscientiousness	−.22**	−.17*	−.16*	.57 (.42–.78)**	.62 (.45–.85)**	.63 (.45–.89)**	−.26**	−.25*	−.30**

Notes. For CN, N = 196 for amyloid and N = 95 for tau. For full sample, N = 216 for amyloid and N = 103 for tau. M1 = No covariates; M2 = Includes age, sex, and time interval between personality and imaging; M3 = Includes M2 covariates, education and depressive symptoms. OR (95% CI) = Odds Ratios (95% Confidence Interval) from logistic regression with personality (z-scores) predicting risk of PiB+.

^*p<.05

^**p<.01.