Figure 4.

Nanoshells loaded with cGAMP to induce synthetic immunogenic cell death for chemoimmunotherapy. A) cGAMP-loaded nanoshells can be readily loaded into dying tumor cells treated with chemotherapeutics. Upon phagocytosis, nanoparticle-laden cancer cells can stimulate an antitumor immune response. B) Fluorescently labeled nanoshells are significantly colocalized with dead tumor cells compared to free CDG. Reproduced with permission (Chattopadhyay et al., 2020). Copyright 2020, American Chemistry Society.