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. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: Mol Aspects Med. 2021 Aug 2;83:101007. doi: 10.1016/j.mam.2021.101007

Figure 5.

Figure 5.

Cationic liposomes enhance cytosolic delivery of cGAMP for melanoma treatment. A) Noncanonical cGAMP is encapsulated inside liposomes fabricated from cholesterol and 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP). The liposomes more readily facilitate intracellular delivery of cGAMP to activate the STING pathway. B) Treatment with PEGylated liposomal formulations prolongs survival in a B16F10 melanoma model. C) After treatment with cGAMP-loaded liposomes, a significant portion of mice are protected from a tumor rechallenge. Reproduced with permission (Koshy et al., 2017). Copyright 2017, Wiley-VCH.