Table 2:

Routes with the highest variations among BRCA, COAD, and STAD cohorts

ID	Route (p1 - Signaling route, p2 - Effector Route)	BRCA		COAD		STAD
		PS	ARS	PS	ARS	PS	ARS
9	Adipocytokine signaling pathway(p1) LEP, LEPR, PPARA, RXRA, RXRB, RXRG	0.99	−0.97	0.1	−0.38	0.1	−0.35
176	IL-17 signaling pathway(p2) FOS, FOSB, JUN, JUND, FOSL1, IL6	0.89	−0.84	0.14	0.22	0.73	−0.65
460	Toll-like receptor signaling pathway(p2) FOS, JUN, IL12A, IL12B, TNF, IL1B, IL6	0.81	−0.41	0.16	0	0.66	−0.34
110	ErbB signaling pathway(p1) EGF, TGFA, AREG, EGFR, ERBB2, STAT5A, STAT5B	0.74	−0.73	0.17	−0.21	0.1	0.06
424	Thyroid hormone signaling pathway(p2) THRA, MYH6, MYH7, ATP2A2, ATP2A1, ATP2A3, PLN	0.78	−0.47	0.23	−0.32	0.14	−0.23
434	Tight junction(p2) YBX3, CDK4, SYMPK, CCND1	0.08	0.25	0.72	0.91	0.17	0.46
299	PPAR signaling pathway(p2) PPARG, RXRA, RXRB, RXRG, SCD5, SCD, FADS2, ME1, ME3	0.69	−0.3	0	0.22	0.11	0.04
400	Th17 cell differentiation(p2) MAPK14, MAPK11, MAPK13, MAPK12, IRF4	0.05	−0.11	0.66	−0.57	0.48	−0.44
432	Tight junction(p2) JUN, CD1A, CD1B, CD1C, CD1D, CD1E	0.59	−0.54	0.1	0.07	0.63	−0.6
472	Wnt signaling pathway(p2) TCF7, TCF7L1, TCF7L2, TCF4, LEF1, FOSL1, JUN, MYC, MMP7, PPARD, WISP1, CCND1, CCND2, CCND3, Cell cycle	0.12	−0.06	0.41	0.25	0.13	0.05