Table 3:

PS scores from GSEA, rPAC, and SPIA (selected routes). The rPAC framework generates scores at route-level resolution distinguishing roles of various routes within a pathway. GSEA and SPIA assign scores for entire pathway with no route-level distinction.

ID	Route (p1 - Signaling, p2 - Effector)	GSEA (FDRq < 0.05)			rPAC (p < 0.05)			SPIA (PG < 0.05)
		BRCA	COAD	STAD	BRCA	COAD	STAD	BRCA	COAD	STAD
		9	Adipocytokine signaling pathway(p1) LEP, LEPR,PPARA, RXRA, RXRB, RXRG	0.62	0.41	0.41	0.99	0.10	0.10	0.14	0.13	0.01
10	Adipocytokine signaling pathway(p1) ADIPOQ, …, RXRB, RXRG	0.62	0.41	0.41	0.35	0.35	0.23	0.14	0.13	0.01
281	PPAR signaling pathway(p2) PPARA, RXRA, RXRB, …, PLIN5, PLIN2	0.83	0.90	0.93	0.86	0.82	0.64	0.01	0.04	0.01
299	PPAR signaling pathway(p2) PPARG, RXRA, … ME1, ME3	0.83	0.90	0.93	0.69	0.00	0.11	0.01	0.04	0.01
432	Tight junction(p2) JUN, CD1A, CD1B, CD1C, CD1D, CD1E	0.49	0.76	0.18	0.59	0.10	0.63	0.01	0.01	0.02
434	Tight junction(p2) YBX3, CDK4, SYMPK, CCND1	0.49	0.76	0.18	0.08	0.72	0.17	0.01	0.01	0.02
471	Wnt signaling pathway(p1)	0.72	0.12	0.32	0.14	0.04	0.07	0.02	0.01	0.06
472	Wnt signaling pathway(p2)	0.72	0.12	0.32	0.12	0.41	0.13	0.02	0.01	0.06