Table 2.

Regression coefficient ± standard error of age and age² terms incorporated in the linear regression for the 14 cerebral white matter structures and for each MR parameter studied. Sex results were not reported as it exhibited nonsignificant effect.

	MWF		FA		MD		RD		AxD
	Age (×10⁻³)	Age² (×10⁻⁵)	Age (×10⁻³)	Age² (×10⁻⁵)	Age (×10⁻⁶)	Age² (×10⁻⁸)	Age (×10⁻⁶)	Age² (×10⁻⁸)	Age (×10⁻⁶)	Age² (×10⁻⁸)
Whole Brain	2.33±0 .63^*	−2.66±0.55^*	0.98±0.39^*	−1.59±0.34^*	−3.50±0.84^*	5.25±0.74^*	−3.52±0.89^*	5.46±0.78^*	−3.41±0.80^*	4.75±0.70^*
Frontal	2.45±0.66^*	−2.90±0.58^*	0.52±0.41^*	−1.33±0.36^*	−2.90±0.89^*	4.73±0.78^*	−2.87±0.95^*	4.95±0.84^*	−2.92±0.82^*	4.27±0.72^*
Occipital	2.77±0.76^*	−2.85±0.67^*	1.13±0.43^*	−1.42±0.37^*	−3.09±1.02^*	4.74±0.89^*	−3.44±1.08^*	5.18±0.95^*	−2.34±0.99^*	3.79±0.87^*
Parietal	2.44±0.69^*	−2.81±0.61^*	0.94±0.42^*	−1.56±0.37^*	−3.63±1.45^*	6.51±1.27^*	−3.67±1.49^*	6.73±1.31^*	−3.60±1.44^*	6.07±1.26^*
Temporal	2.38±0.70^*	−2.65±0.62^*	1.05±0.53^*	−1.73±0.47^*	−4.11±0.89^*	5.63±0.78^*	−4.31±1.00^*	6.08±0.88^*	−3.66±0.82^*	4.65±0.72^*
Cerebellum	1.80±0.68^*	−1.94±0.60^*	1.60±0.63	−1.56±0.56^*	−2.93±1.03^*	2.89±0.90^*	−3.07±1.07^*	3.04±0.94^*	−2.60±1.21	2.52±1.06^*
Corpus Callosum	1.87±0.64^*	−2.31±0.57^*	0.94±1.18^*	−2.55±1.04^*	−2.24±1.85^*	5.39±1.63^*	−2.15±2.29^*	6.08±2.01^*	−2.73±1.75^*	4.21±1.54^*
Internal Capsule	1.97±0.64^*	−2.37±0.56^*	2.74±0.88^*	−2.86±0.77^*	−5.37±1.13^*	6.20±0.99^*	−4.84±1.18^*	5.62±1.03^*	−6.50±1.34^*	7.38±1.17^*
Cerebral Peduncle	2.00±0.59	−1.93±0.52^*	−0.62±0.82^*	−0.063±0.72	−2.78±1.28^*	3.97±1.12^*	−1.79±1.28^*	3.23±1.13^*	−4.69±1.67^*	5.28±1.47^*
Corona Radiata	2.43±0.79^*	−3.03±0.70^*	1.09±0.62^*	−1.83±0.54^*	−2.71±1.03^*	4.17±0.90^*	−2.78±1.09^*	4.40±0.95^*	−2.50±1.09^*	3.61±0.96^*
Thalamic Radiation	1.68±0.71^*	−2.22±0.63^*	1.51±0.58^*	−2.10±0.51^*	−2.82±0.93^*	3.91±0.81^*	−3.16±1.00^*	4.41±0.87^*	−1.84±0.94^*	2.59±0.83^*
Fronto Occipital Fasciculus	2.21±0.69^*	−2.70±0.61^*	1.24±0.71^*	−1.54±0.62^*	−3.46±1.02^*	4.78±0.90^*	−3.68±1.09^*	4.94±0.96^*	−3.08±1.13^*	4.47±1.00^*
Longitudinal Fasciculus	2.19±0.70^*	−2.60±0.62^*	0.63±0.71^*	−1.16±0.62	−2.51±0.74^*	3.26±0.65^*	−2.53±0.86^*	3.45±0.76^*	−2.33±0.91^*	2.70±0.80^*
Forceps	2.21±0.70^*	−2.64±0.61^*	1.32±0.65^*	−2.34±0.57^*	−3.07±0.89^*	4.71±0.78^*	−3.45±1.04^*	5.51±0.91^*	−2.31±0.91^*	3.06±0.80^*

indicates significance at p < 0.05 after FDR correction. The actual p-values are provided in the Supplementary Material (Table S1).