Table 2.

Histologic and immunohistochemical characteristics of the patients’ cohort.

Case	Reconstruction	Histology	Type	Differentiation	CK7		CK20		GATA-3		CK903
					% Tumor positive	Intensity	% Tumor positive	Intensity	% Tumor positive	Intensity	% Tumor positive	Intensity
1	Ileal conduit	Adenocarcinoma gastric type	Gastric	Moderately differentiated	90	3+	0	0	0	0	20	3+
2	Ileal conduit	Adenocarcinoma intestinal/villous type	Intestinal/villous	Well-differentiated	70	3+	80	3+	0	0	5	3+
3	Ileal conduit	Treatment effect	NA	NA	0	0	80	2+	0	0	0	0
4	Ileal conduit	Squamous cell carcinoma	NA	Well-differentiated	ND	ND	ND	ND	ND	ND	ND	ND
5	Ileal conduit	Adenocarcinoma with signet ring features	Signet ring features	Poorly differentiated	0	0	20	3+	0	0	0	0
6	Gastrocystoplasty	Adenocarcinoma intestinal type	Intestinal	Poorly differentiated	50	2+	5	2+	0	0	30	3+
7	Gastrocystoplasty	Adenocarcinoma gastric type	Gastric	Well-differentiated	80	3+	20	3+	0	0	5	2+
8	Colo-cystoplasty converted to ileal conduit	Adenocarcinoma intestinal/villous type	Intestinal/villous	Well-differentiated	0	0	10	2+	0	0	10	3+
9	Ileal conduit	Adenocarcinoma intestinal/villous type	Intestinal/villous	Well-differentiated	ND	ND	ND -	ND	ND	ND	ND	ND
10	Indiana pouch	Adenocarcinoma intestinal/villous type	Intestinal/villous	Poorly differentiated	0	0	100	3+	0	0	10	3+
11	Augmentation cystoplasty	Adenocarcinoma intestinal/villous type	Intestinal/villous	NA	0	0	80	3+	0	0	5	3+

Case	Reconstruction	Histology	Type	Differentiation	CDX2		SATB2		Beta-catenin
					% Tumor positive	Intensity	% Tumor positive	Intensity	% Tumor positive	Intensity Pattern
1	Ileal conduit	Adenocarcinoma gastric type	Gastric	Moderately differentiated	5	2+	0	0	60	3+	M, C, N
2	Ileal conduit	Adenocarcinoma intestinal/villous type	Intestinal/villous	Well-differentiated	80	3+	20	2+	100	3+	M, C
3	Ileal conduit	Treatment effect	NA	NA	100	3+	50	2+	100	2+	Focal M,C
4	Ileal conduit	Squamous cell carcinoma	NA	Well-differentiated	ND	ND	ND	ND	ND	ND	ND
5	Ileal conduit	Adenocarcinoma with signet ring features	Signet ring features	Poorly differentiated	100	3+	40	2+	100	2+	M, C
6	Gastrocystoplasty	Adenocarcinoma intestinal type	Intestinal	Poorly differentiated	10	2+	0	0	100	3+	M, C, N
7	Gastrocystoplasty	Adenocarcinoma gastric type	Gastric	Well-differentiated	0	0	0	0	100	3+	M, C
8	Colo-cystoplasty converted to ileal conduit	Adenocarcinoma intestinal/villous type	Intestinal/villous	Well-differentiated	90	3+	5	2+	100	3+	M, C, N
9	Ileal conduit	Adenocarcinoma intestinal/villous type	Intestinal/villous	Well-differentiated	ND	ND	ND	ND	ND	ND	ND
10	Indiana pouch	Adenocarcinoma intestinal/villous type	Intestinal/villous	Poorly differentiated	100	3+	100	3+	100	3+	M, C, N
11	Augmentation cystoplasty	Adenocarcinoma intestinal/villous type	Intestinal/villous	NA	100	3+	60	2+	100	3+	M, C, N

Abbreviations: M, membranous; C, cytoplasmic; N, nuclear.