Table 1:

Genes that are associated with the development and evolution of limb skeletal proportion.

Gene Symbol	Gene Name	Known Skeletal/Body Size Phenotypes
Alpl	alkaline phosphatase, liver/bone/kidney	Abnormal long bone metaphysis morphology28 Decreased long bone epiphyseal plate size28 Decreased bone mineral density29 Increased bone resorption30 Decreased body size31
B2m	beta-2 microglobulin	None reported
Baiap2l2	BAI1-associated protein 2-like 2	None reported
Enpp2	ectonucleotide pyrophosphatase/phosphodiesterase 2	None reported
Ibsp	integrin binding sialoprotein	Abnormal trabecular bone morphology32 Decreased bone mineral density32 Increased bone resorption33 Decreased body size32 Short femur32
Lmcd1	LIM and cysteine-rich domains 1	None reported
Mcoln3	mucolipin 3	Decreased body size34
Myh10	myosin, heavy polypeptide 10, non-muscle	Abnormal body size35
Nlgn3	neuroligin 3	None reported
Npr3*	natriuretic peptide receptor 3	Increased width of hypertrophic chondrocyte zone36 Delayed endochondral bone ossification37 Increased length of long bones36,38 Elongated metatarsal bones38 Increased body length36,38,39
Nprl3	nitrogen permease regulator-like 3	None reported
Tbx18	T-box18	Abnormal skeleton morphology40,41 Decreased body length41,42
Ttll9	tubulin tyrosine ligase-like family, member 9	None reported

Asterisk designates Npr3, which also appears in the human SHR GWAS. See also Table S5.