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. Author manuscript; available in PMC: 2023 Feb 1.
Published in final edited form as: J Stroke Cerebrovasc Dis. 2021 Dec 9;31(2):106237. doi: 10.1016/j.jstrokecerebrovasdis.2021.106237

Table 3:

Cox proportional hazard models for incident ischemic stroke.

Hazard ratio (95% CI) for ischemic stroke*
Model Quartile 1 Quartile 2 Quartile 3 Quartile 4 P trend Hazard ratio per 1 SD higher
N = 313 N = 342 N = 355 N = 394
1 1 (ref) 1.21 (0.84, 1.72) 1.31 (0.92, 1.85) 2.24 (1.58, 3.16) <0.001 1.32 (1.16, 1.49)
2 1 (ref) 1.05 (0.73, 1.51) 0.96 (0.66, 1.38) 1.35 (0.92, 1.99) 0.2 1.14 (0.99, 1.34)
3 1 (ref) 1.04 (0.65, 1.65) 0.92 (0.58, 1.46) 1.40 (0.86, 2.27) 0.2 1.19 (1.00, 1.41)
4 1 (ref) 1.08 (0.68, 1.73) 1.00 (0.62, 1.60) 1.44 (0.88, 2.35) 0.2 1.20 (1.01, 1.42)
*

Model 1 was unadjusted. Model 2 was adjusted for age, sex, race, and age-by-sex interaction. Model 3 added geographic region of residence, annual income, education, and Framingham stroke risk factors to Model 2. Model 4 added baseline use of statins, NSAIDs, or aspirin to Model 3. All models were weighted to reflect the entire REGARDS cohort. SD, standard deviation (0.37 ln(pmol/L)).