Table 4.
Spearman’s Rho (ρ) coefficients between sphingolipid pmole and dry eye (DE) symptoms and signs.
Spearman’s ρ |
DE Symptoms | MGD/DE Signs | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
DEQ-5 | OSDI | Meibomian Quality |
Eyelid Vascularity |
Meibomian Dropout |
Meibomian Plugging |
TBUT | Fluorescein Stain |
Schirmer Test |
MMP | |
In meibum (total pmole) | ||||||||||
Cer | −0.37** | −0.38** | 0.46*** | −0.16 | 0.37*** | 0.23 | 0.03 | −0.02 | 0.32* | 0.12 |
Hex-Cer | −0.21 | −0.25 | 0.40** | −0.09 | 0.28 | 0.15 | 0.13 | −0.15 | 0.37*** | −0.05 |
SM | −0.30* | −0.32* | 0.66*** | 0.03 | 0.37*** | 0.03 | −0.08 | 0.0 | 0.15 | −0.03 |
Sph | 0.02 | −0.09 | 0.13 | −0.06 | 0.10 | 0.31* | 0.02 | 0.06 | 0.22 | 0.19 |
Sa | −0.21 | −0.23 | 0.31* | −0.28 | 0.17 | 0.23 | 0.17 | −0.06 | 0.30* | −0.03 |
SPL | −0.27 | −0.21 | 0.64*** | −0.28 | 0.34* | 0.20 | 0.003 | −0.12 | 0.31* | −0.02 |
In tears (total pmole) | ||||||||||
Cer | −0.12 | −0.06 | 0.04 | −0.09 | 0.15 | 0.09 | −0.19 | 0.12 | −0.42 | −0.046 |
Cer/SM | 0.08 | 0.08 | −0.14 | −0.01 | −0.08 | −0.11 | −0.06 | −0.006 | −0.40** | 0.04 |
Hex-Cer | −0.10 | 0.005 | 0.17 | −0.28 | 0.25 | 0.22 | −0.18 | 0.21 | −0.03 | 0.03 |
Hex-Cer/SM | −0.02 | 0.07 | 0.07 | −0.20 | 0.20 | 0.20 | −0.007 | 0.18 | −0.01 | 0.09 |
SM | −0.20 | −0.11 | 0.11 | −0.14 | 0.23 | 0.16 | −0.21 | 0.14 | −0.33* | −0.09 |
Sph | −0.19 | 0.005 | 0.32 | −0.32 | 0.20 | 0.18 | −0.02 | 0.14 | 0.10 | −0.14 |
S1P | 0.18 | 0.31 | −0.17 | −0.08 | −0.01 | 0.03 | 0.03 | 0.07 | −0.003 | −0.03 |
SPL | −0.16 | −0.05 | 0.07 | −0.14 | 0.19 | 0.14 | −0.19 | 0.14 | −0.32* | −0.07 |
DE=Dry Eye, SPL=total sphingolipid, Cer=ceramide, Hex-Cer=hexosyl ceramide, SM=sphingomyelin, Sph=sphingosine, Sa=sphinganine, S1P=sphingosine 1-phosphate, TBUT=Tear Break-Up Time, MMP=Matrix Metallopeptidase-9, OSDI=Ocular Surface Disease Index, DEQ-5=Dry Eye Questionnaire, ρ Rho=coefficient for dependent variables
Statistically significant difference at p-values <0.05
p-value <0.01
p-value <0.001.