Table 2: Serum/plasma MFI of cytokines commonly assessed in cell therapy trials.
Ratio of serum/plasma mean fluorescence intensity (MFI) of cytokines measured in cell therapy trials. Representative NCT numbers were sourced from Berranondo et al. [39] and clinicaltrials.gov. Ratio of MFI values referenced from Rosenberg-Hasson et al. [38]
| Cytokine | Representative cytokine clinical trials | Ratio of serum/plasma MFI |
|---|---|---|
| GM-CSF |
NCT02933333
NCT04408092 |
2.615 |
|
NCT01495637
NCT03769844 NCT02502786 |
||
| IFNα | NCT04534634 | 1.206 |
| IFNγ |
NCT01965327
NCT02593773 NCT03548818 NCT02797080 NCT03378102 NCT03063632 |
1.584 |
| IL-1α | N/A | 1.491 |
| IL-1β | N/A | 2.225 |
| IL-1RA |
NCT04169022
NCT02780583 |
1.226 |
| IL-2 |
NCT03138889
NCT02983045 NCT03282344 NCT03435640 NCT02983045 NCT02350673 NCT02627274 NCT03386721 NCT03063762 NCT03063762 |
2.259 |
| IL-4 | N/A | 2.134 |
| IL-6 | N/A | 4.058 |
| IL-8 | NCT03400332 | 1.280 |
| IL-10 | NCT02923921 | 1.433 |
| IL-15 |
NCT02989844
NCT01875601 NCT02465957 NCT01385423 NCT01369888 NCT02689453 NCT02384954 |
2.868 |
| TNFα | NCT03293784 | 1.986 |
| TGFβ |
NCT02423343
NCT02734160 NCT02581787 NCT03451773 NCT03451773 |
2.506 |
| VEGF | NCT01984242 | 3.393 |