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A list of suggested markers to evaluate immune effector cell (IEC) activation or exhaustion status as a part of cell therapy trials.
| Marker | Role |
|---|---|
| CD3 | Lineage |
| CD4 | Lineage |
| CD8 | Lineage |
| CD25 | Activation |
| TIM-3 (CD366) | Exhaustion |
| CTLA-4 (CD152) | Exhaustion |
| LAG-3 (CD223) | Exhaustion |
| PD-1 (CD279) | Exhaustion |
| Perforin or Granzyme B* | Function |
| IFNγ* | Function |
| TNFα* | Function |
| IL-2* | Function |
Indicates intracellular staining required.
