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Screening bicyclic moieties based on 10 (38017).
| |||||||
|---|---|---|---|---|---|---|---|
| Cmpd | R2 | EC50 (μM) | CC50 (μM) | Cmpd | R2 | EC50 (μM) | CC50 (μM) |
| 33 |
|
0.75 | > 12.5 | 34 |
|
2.39 | > 12.5 |
| 35 |
|
> 10 | > 50 | 36 |
|
5.02 | > 100 |
| 37 |
|
0.11 | > 100 | 38 |
|
0.73 | > 100 |
| 39 |
|
2.18 | 4.6 | 40 |
|
1.48 | > 50 |
| 41 |
|
4.48 | > 33.3 | 42 |
|
1.64 | > 33.3 |
| 43 |
|
5.57 | > 50 | 44 |
|
13.36 | - |
