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New bicyclic scaffold Screening.
| |||||||
|---|---|---|---|---|---|---|---|
| Cmpd | R2 | EC50 (μM) | CC50 (μM) | Cmpd | R2 | EC50 (μM) | CC50 (μM) |
| 46 |
|
1.32 | > 12.5 | 51 |
|
> 10 | > 100 |
| 52 |
|
4.83 | > 100 | 53 |
|
2.89 | > 50 |
| 54 |
|
5.01 | > 100 | 55 |
|
5.11 | > 20 |
| 56 |
|
1.67 | > 100 | 57 |
|
9.4 | 25 |
| 58 |
|
0.71 | > 100 | 59 |
|
1.81 | > 100 |
| 60 |
|
1.86 | > 100 | 61 |
|
0.46 | > 100 |
| 62 |
|
> 10 | > 100 | 63 |
|
> 10 | > 100 |
| 45 |
|
0.52 | > 100 | 64 |
|
> 10 | 26.3 |
| 65 |
|
> 10 | > 100 | 66 |
|
> 10 | > 100 |
