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Optimization of octahydroquinolin-4(1H)-one-based analogs.
| |||||||
|---|---|---|---|---|---|---|---|
| Cmpd | R1 | EC50 (μM) | CC50 (μM) | Cmpd | R1 | EC50 (μM) | CC50 (μM) |
| 70 |
|
0.38 | > 20 | 71 |
|
0.26 | > 20 |
| 72 |
|
0.97 | > 20 | 73 |
|
0.85 | > 20 |
| 74 |
|
0.22 | > 20 | 75 |
|
2.41 | > 100 |
| 76 |
|
> 10 | > 50 | 77 |
|
> 10 | > 100 |
