Table 6.
Evaluation of new compounds in liver microsomes assays.
| Cmpd | 46 | 56 | 58 | 59 | 71 | 60 | 61 | 45 | |
|---|---|---|---|---|---|---|---|---|---|
| T1/2 (min) | mouse | 10.0 | 5.8 | 32.0 | 7.8 | 35 | 7 | 56 | <4.0 |
| human | 47.2 | 56.8 | 5.0 | 69 | 48 | 71 | 14.7 | ||
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