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. Author manuscript; available in PMC: 2023 Feb 5.
Published in final edited form as: Biochem Biophys Res Commun. 2021 Dec 29;591:13–19. doi: 10.1016/j.bbrc.2021.12.090

Figure 3: PAR2-dependent in vitro physiological response to A. alternata.

Figure 3:

16HBE14o− (A) or 16HBEPAR−/− cells (B) were treated with 30 ng/mL – 10 μg/mL A. alternata filtrate and Cell Index was measured every minute for 2 hrs. A. alternata induced a distinctly different response in the PAR2-expressing parental cell line (16HBE14o−). Notably, the initial dip in signaling followed by a rapid peak and recovery was missing in the PAR2-ablated cell line (16HBEPAR2−/−). Traces are mean, normalized values from 6 experiments.